Protein induced lipid demixing in homogeneous membranes

Specific lipid environments are necessary for the establishment of protein signaling platforms in membranes, yet their origin has been highly debated. We present a continuum, exactly solvable model induced local demixing membranes. The coupling between composition and thickness membrane induces domains around inclusions with hydrophobic mismatch, even temperatures above miscibility critical point membrane. qualitatively explains experimentally observed formation by anchoring reconstituted actin flat supported bilayers.Received 31 May 2021Accepted 14 September 2021DOI:https://doi.org/10.1103/PhysRevResearch.3.L042013Published American Physical Society under terms Creative Commons Attribution 4.0 International license. Further distribution this work must maintain attribution to author(s) published article's title, journal citation, DOI.Published SocietyPhysics Subject Headings (PhySH)Research AreasPhase separationProtein-membrane interactionsProtein-protein interactionsStructural order parameterTechniquesLandau-Ginzburg theoryPath-integral methodsBiological PhysicsStatistical PhysicsCondensed Matter, Materials & Applied Physics